The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.

Détails

ID Serval
serval:BIB_65E4DCA6F4DB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Périodique
Cell death and differentiation
Auteur(s)
Rebsamen M., Meylan E., Curran J., Tschopp J.
ISSN
1350-9047 (Print)
ISSN-L
1350-9047
Statut éditorial
Publié
Date de publication
11/2008
Peer-reviewed
Oui
Volume
15
Numéro
11
Pages
1804-1811
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds) RNA, transmits downstream antiviral signaling through the TIR adaptor Trif (TICAM-1), viral RNA-sensing RIG-like helicases (RLHs) use the mitochondrial-bound CARD protein Cardif (IPS-1/MAVS/VISA). The importance of these two antiviral signaling pathways is reflected by the fact that both adaptors are inhibited through specific cleavage triggered by the hepatitis C virus serine protease NS3-4A. Here, we show that inactivation can also occur through cellular caspases activated by various pro-apoptotic signals. Upon caspase-dependent cleavage both adaptors loose their capacity to activate the transcription factors interferon regulatory factors (IRF) and NF-kappaB. Importantly, poliovirus infection triggers a caspase-dependent cleavage of Cardif, suggesting that some viruses may activate caspases not only as a mean to facilitate shedding and replication, but also to impair antiviral responses.
Mots-clé
Adaptor Proteins, Signal Transducing/metabolism, Adaptor Proteins, Vesicular Transport/metabolism, Antiviral Agents/metabolism, Caspases/metabolism, HeLa Cells, Humans, Interferon Regulatory Factors/metabolism, Models, Biological, Poliovirus/physiology, Protein Processing, Post-Translational
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/08/2020 16:45
Dernière modification de la notice
13/08/2020 5:26
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