The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.

Details

Serval ID
serval:BIB_65E4DCA6F4DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases.
Journal
Cell death and differentiation
Author(s)
Rebsamen M., Meylan E., Curran J., Tschopp J.
ISSN
1350-9047 (Print)
ISSN-L
1350-9047
Publication state
Published
Issued date
11/2008
Peer-reviewed
Oui
Volume
15
Number
11
Pages
1804-1811
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds) RNA, transmits downstream antiviral signaling through the TIR adaptor Trif (TICAM-1), viral RNA-sensing RIG-like helicases (RLHs) use the mitochondrial-bound CARD protein Cardif (IPS-1/MAVS/VISA). The importance of these two antiviral signaling pathways is reflected by the fact that both adaptors are inhibited through specific cleavage triggered by the hepatitis C virus serine protease NS3-4A. Here, we show that inactivation can also occur through cellular caspases activated by various pro-apoptotic signals. Upon caspase-dependent cleavage both adaptors loose their capacity to activate the transcription factors interferon regulatory factors (IRF) and NF-kappaB. Importantly, poliovirus infection triggers a caspase-dependent cleavage of Cardif, suggesting that some viruses may activate caspases not only as a mean to facilitate shedding and replication, but also to impair antiviral responses.
Keywords
Adaptor Proteins, Signal Transducing/metabolism, Adaptor Proteins, Vesicular Transport/metabolism, Antiviral Agents/metabolism, Caspases/metabolism, HeLa Cells, Humans, Interferon Regulatory Factors/metabolism, Models, Biological, Poliovirus/physiology, Protein Processing, Post-Translational
Pubmed
Web of science
Open Access
Yes
Create date
11/08/2020 16:45
Last modification date
13/08/2020 5:26
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