Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers
Details
Serval ID
serval:BIB_64E755ECB5C5
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers
Journal
Journal of Nutrition
ISSN
0022-3166 (Print)
Publication state
Published
Issued date
02/1992
Volume
122
Number
2
Pages
312-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Abstract
Inhaled cigarette smoke releases a variety of oxidizing agents. Ascorbic acid is recognized as an important biological antioxidant. To better characterize the antioxidant protective role of ascorbic acid, a comparison of ascorbic acid concentrations in plasma, leukocytes, bronchoalveolar lavage fluid and alveolar macrophages from a homogeneous group of healthy male smokers (n = 10) and nonsmokers (n = 14) was investigated. The resulting ascorbic acid contents were (means +/- SD) 91 +/- 25 (n = 10) and 87 +/- 25 (n = 14) mumol/L in plasma, 2.09 +/- 0.62 (n = 7) and 2.12 +/- 0.77 (n = 11) mumol/10(9) cells in mononuclear leukocytes, 3.2 +/- 2.2 (n = 10) and 1.7 +/- 1.5 (n = 13) mumol/L in bronchoalveolar lavage fluid and 3.4 +/- 2.3 (n = 8) and 1.6 +/- 1.3 (n = 6) mumol/10(9) cells in alveolar macrophages from smokers and nonsmokers, respectively. Mean daily dietary vitamin C intake was 116 +/- 68 and 107 +/- 59 mg/d for smokers and nonsmokers, respectively. The ascorbic acid contents of bronchoalveolar lavage [3.9 +/- 1.9 mumol/L (n = 8)] and alveolar macrophages [4.1 +/- 2.1 mumol/10(9) cells (n = 6)] of smokers consuming 15 to 20 cigarettes/d were significantly higher (P less than 0.05) than those of nonsmokers. The increased content of ascorbic acid in bronchoalveolar lavage and in alveolar macrophages of smokers compared with nonsmokers may reflect a defensive mechanism against free radical species derived from cigarette smoke.
Keywords
Adult
Ascorbic Acid/*administration & dosage/analysis/blood
Bronchoalveolar Lavage Fluid/*chemistry
Energy Intake
Humans
Leukocytes, Mononuclear/*chemistry
Macrophages, Alveolar/*chemistry
Male
Smoking/*metabolism
Pubmed
Web of science
Create date
25/01/2008 10:52
Last modification date
20/08/2019 15:21