Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers

Détails

ID Serval
serval:BIB_64E755ECB5C5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers
Périodique
Journal of Nutrition
Auteur⸱e⸱s
Bui  M. H., Sauty  A., Collet  F., Leuenberger  P.
ISSN
0022-3166 (Print)
Statut éditorial
Publié
Date de publication
02/1992
Volume
122
Numéro
2
Pages
312-6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
Inhaled cigarette smoke releases a variety of oxidizing agents. Ascorbic acid is recognized as an important biological antioxidant. To better characterize the antioxidant protective role of ascorbic acid, a comparison of ascorbic acid concentrations in plasma, leukocytes, bronchoalveolar lavage fluid and alveolar macrophages from a homogeneous group of healthy male smokers (n = 10) and nonsmokers (n = 14) was investigated. The resulting ascorbic acid contents were (means +/- SD) 91 +/- 25 (n = 10) and 87 +/- 25 (n = 14) mumol/L in plasma, 2.09 +/- 0.62 (n = 7) and 2.12 +/- 0.77 (n = 11) mumol/10(9) cells in mononuclear leukocytes, 3.2 +/- 2.2 (n = 10) and 1.7 +/- 1.5 (n = 13) mumol/L in bronchoalveolar lavage fluid and 3.4 +/- 2.3 (n = 8) and 1.6 +/- 1.3 (n = 6) mumol/10(9) cells in alveolar macrophages from smokers and nonsmokers, respectively. Mean daily dietary vitamin C intake was 116 +/- 68 and 107 +/- 59 mg/d for smokers and nonsmokers, respectively. The ascorbic acid contents of bronchoalveolar lavage [3.9 +/- 1.9 mumol/L (n = 8)] and alveolar macrophages [4.1 +/- 2.1 mumol/10(9) cells (n = 6)] of smokers consuming 15 to 20 cigarettes/d were significantly higher (P less than 0.05) than those of nonsmokers. The increased content of ascorbic acid in bronchoalveolar lavage and in alveolar macrophages of smokers compared with nonsmokers may reflect a defensive mechanism against free radical species derived from cigarette smoke.
Mots-clé
Adult Ascorbic Acid/*administration & dosage/analysis/blood Bronchoalveolar Lavage Fluid/*chemistry Energy Intake Humans Leukocytes, Mononuclear/*chemistry Macrophages, Alveolar/*chemistry Male Smoking/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 10:52
Dernière modification de la notice
20/08/2019 15:21
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