Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.

Details

Serval ID
serval:BIB_6448AD630AF8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.
Journal
Physiological reviews
Author(s)
Riera-Domingo C., Audigé A., Granja S., Cheng W.C., Ho P.C., Baltazar F., Stockmann C., Mazzone M.
ISSN
1522-1210 (Electronic)
ISSN-L
0031-9333
Publication state
Published
Issued date
01/01/2020
Peer-reviewed
Oui
Volume
100
Number
1
Pages
1-102
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Abstract
It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.
Keywords
Animals, Humans, Hypoxia, Immunity, Immunotherapy, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/therapy, Tumor Microenvironment, cancer, hypoxia, immunometabolism, immunotherapy, metabolism
Pubmed
Web of science
Create date
11/09/2019 14:12
Last modification date
05/09/2020 5:26
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