Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.

Détails

ID Serval
serval:BIB_6448AD630AF8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Immunity, Hypoxia, and Metabolism-the Ménage à Trois of Cancer: Implications for Immunotherapy.
Périodique
Physiological reviews
Auteur(s)
Riera-Domingo C., Audigé A., Granja S., Cheng W.C., Ho P.C., Baltazar F., Stockmann C., Mazzone M.
ISSN
1522-1210 (Electronic)
ISSN-L
0031-9333
Statut éditorial
Publié
Date de publication
01/01/2020
Peer-reviewed
Oui
Volume
100
Numéro
1
Pages
1-102
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and ultimately impairs immune cell fitness and effector functions. The major aims of this review are to provide an overview on the immune system in cancer; to position oxygen shortage and metabolic competition as the ground of a restrictive TME and as important players in the anti-tumor immune response; to define how immunotherapies affect hypoxia/oxygen delivery and the metabolic landscape of the tumor; and vice versa, how oxygen and metabolites within the TME impinge on the success of immunotherapies. By analyzing preclinical and clinical endeavors, we will discuss how a metabolic characterization of the TME can identify novel targets and signatures that could be exploited in combination with standard immunotherapies and can help to predict the benefit of new and traditional immunotherapeutic drugs.
Mots-clé
Animals, Humans, Hypoxia, Immunity, Immunotherapy, Neoplasms/immunology, Neoplasms/metabolism, Neoplasms/therapy, Tumor Microenvironment, cancer, hypoxia, immunometabolism, immunotherapy, metabolism
Pubmed
Web of science
Création de la notice
11/09/2019 15:12
Dernière modification de la notice
05/09/2020 6:26
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