Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
MicroRNAs: a new insight into cancer genome.
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Cancer is a disease involving multi-step dynamic changes in the genome. However, studies on cancer genome so far have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional noncoding sequences in cancer is largely absent. MicroRNAs (miRNA) are approximately 22 nt noncoding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence is showing that miRNAs may play important roles in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.
Epigenesis, Genetic, Gene Dosage, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Humans, MicroRNAs/genetics, MicroRNAs/physiology, Mutation
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