MicroRNAs: a new insight into cancer genome.

Détails

ID Serval
serval:BIB_63F2B846D13C
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
MicroRNAs: a new insight into cancer genome.
Périodique
Cell Cycle
Auteur(s)
Zhang L., Coukos G.
ISSN
1551-4005 (Electronic)
ISSN-L
1551-4005
Statut éditorial
Publié
Date de publication
2006
Volume
5
Numéro
19
Pages
2216-2219
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Cancer is a disease involving multi-step dynamic changes in the genome. However, studies on cancer genome so far have focused most heavily on protein-coding genes, and our knowledge on alterations of the functional noncoding sequences in cancer is largely absent. MicroRNAs (miRNA) are approximately 22 nt noncoding RNAs, which regulate gene expression in a sequence-specific manner via translational inhibition or mRNA degradation. Mounting evidence is showing that miRNAs may play important roles in tumor development, and a better understanding of their alteration in cancer genome and oncogenic property should contribute to the diagnosis and treatment of cancer.
Mots-clé
Epigenesis, Genetic, Gene Dosage, Gene Expression Regulation, Neoplastic, Genes, Neoplasm, Humans, MicroRNAs/genetics, MicroRNAs/physiology, Mutation
Pubmed
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 15:20
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