Article: article from journal or magazin.
Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin
Journal of Cardiovascular Pharmacology
6 Suppl 5
Such compounds as clonidine, guanabenz and guanfacine, which stimulate central alpha-adrenoceptors, reduce blood pressure predominantly by reducing sympathetic outflow. Notwithstanding, they also tend to reduce renin secretion, aldosterone, and even vasopressin levels. In some clinical settings, inactivation of the renin-angiotensin system may contribute to their antihypertensive effect. In addition, the absence of sodium retention, which appears to be a special feature of guanabenz, may also have a beneficial effect on blood pressure. In contrast, it is unlikely that a decrease in vasopressin secretion has any major influence on blood pressure.
Adrenergic alpha-Agonists/pharmacology Animals Antihypertensive Agents/*pharmacology Blood Pressure/drug effects Clonidine/pharmacology Guanabenz/pharmacology Guanfacine Guanidines/pharmacology Humans Phenylacetates/pharmacology Renin/blood Renin-Angiotensin System/*drug effects Sodium/blood Vasopressins/*blood
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