Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin

Détails

ID Serval
serval:BIB_63839312DE6C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Effect of centrally acting antihypertensive drugs on the renin-angiotensin system and vasopressin
Périodique
Journal of Cardiovascular Pharmacology
Auteur⸱e⸱s
Waeber  B., Nussberger  J., Brunner  H. R.
ISSN
0160-2446 (Print)
Statut éditorial
Publié
Date de publication
1984
Volume
6 Suppl 5
Pages
S799-802
Notes
Journal Article
Résumé
Such compounds as clonidine, guanabenz and guanfacine, which stimulate central alpha-adrenoceptors, reduce blood pressure predominantly by reducing sympathetic outflow. Notwithstanding, they also tend to reduce renin secretion, aldosterone, and even vasopressin levels. In some clinical settings, inactivation of the renin-angiotensin system may contribute to their antihypertensive effect. In addition, the absence of sodium retention, which appears to be a special feature of guanabenz, may also have a beneficial effect on blood pressure. In contrast, it is unlikely that a decrease in vasopressin secretion has any major influence on blood pressure.
Mots-clé
Adrenergic alpha-Agonists/pharmacology Animals Antihypertensive Agents/*pharmacology Blood Pressure/drug effects Clonidine/pharmacology Guanabenz/pharmacology Guanfacine Guanidines/pharmacology Humans Phenylacetates/pharmacology Renin/blood Renin-Angiotensin System/*drug effects Sodium/blood Vasopressins/*blood
Pubmed
Web of science
Création de la notice
05/03/2008 16:39
Dernière modification de la notice
20/08/2019 14:20
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