Endothelial dysfunction in systemic lupus erythematosus: evaluation with 13N-ammonia PET.

Details

Serval ID
serval:BIB_62AD4CFABEBC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Endothelial dysfunction in systemic lupus erythematosus: evaluation with 13N-ammonia PET.
Journal
Journal of Nuclear Medicine
Author(s)
Alexánderson E., Ochoa J.M., Calleja R., Juárez-Rojas J.G., Prior J.O., Jácome R., Romero E., Meave A., Posadas-Romero C.
ISSN
1535-5667[electronic], 0161-5505[linking]
Publication state
Published
Issued date
2010
Volume
51
Number
12
Pages
1927-1931
Language
english
Abstract
Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with N-13-ammonia PET in asymptomatic SLE patients. Methods: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %Delta MBF, and myocardial flow reserve (MFR) were calculated. Results: There were 16 women in the SLE group (mean age +/- SD, 31.4 +/- 8.3 y) and 16 women in the healthy control group (31.5 +/- 11.1 y). Mean endothelium-dependent vasodilatation index and %Delta MBF were significantly lower in SLE patients (1.18 +/- 0.55 vs. 1.63 +/- 0.65, P = 0.04, and 18 +/- 55 vs. 63 +/- 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 +/- 0.59 vs. 2.73 +/- 0.77, P = 0.20). Conclusion: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients.
Pubmed
Web of science
Open Access
Yes
Create date
14/12/2010 17:46
Last modification date
20/08/2019 15:19
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