Endothelial dysfunction in systemic lupus erythematosus: evaluation with 13N-ammonia PET.

Détails

ID Serval
serval:BIB_62AD4CFABEBC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Endothelial dysfunction in systemic lupus erythematosus: evaluation with 13N-ammonia PET.
Périodique
Journal of Nuclear Medicine
Auteur⸱e⸱s
Alexánderson E., Ochoa J.M., Calleja R., Juárez-Rojas J.G., Prior J.O., Jácome R., Romero E., Meave A., Posadas-Romero C.
ISSN
1535-5667[electronic], 0161-5505[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
51
Numéro
12
Pages
1927-1931
Langue
anglais
Résumé
Systemic lupus erythematosus (SLE) affects multiple organs and systems, severely involving the cardiovascular system. The aim of this study was to evaluate the presence of endothelial dysfunction with N-13-ammonia PET in asymptomatic SLE patients. Methods: We enrolled 16 women with SLE and 16 healthy women. Myocardial blood flow (MBF) was quantified in a 64-slice PET/CT scanner at rest, during a cold pressor test (CPT), and during stress. Endothelium-dependent vasodilation index, %Delta MBF, and myocardial flow reserve (MFR) were calculated. Results: There were 16 women in the SLE group (mean age +/- SD, 31.4 +/- 8.3 y) and 16 women in the healthy control group (31.5 +/- 11.1 y). Mean endothelium-dependent vasodilatation index and %Delta MBF were significantly lower in SLE patients (1.18 +/- 0.55 vs. 1.63 +/- 0.65, P = 0.04, and 18 +/- 55 vs. 63 +/- 65, P = 0.04, respectively). MFR was also lower in the SLE group (2.41 +/- 0.59 vs. 2.73 +/- 0.77, P = 0.20). Conclusion: SLE patients who are free of active disease present abnormal coronary flow and endothelial dysfunction. It is necessary to develop and intensify treatment strategies directed to CAD in SLE patients.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/12/2010 17:46
Dernière modification de la notice
20/08/2019 15:19
Données d'usage