Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.

Détails

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Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_6214CD4B88BA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Coat color dilution in mice because of inactivation of the melanoma antigen MART-1.
Périodique
Pigment Cell and Melanoma Research
Auteur(s)
Aydin I.T., Hummler E., Smit N.P., Beermann F.
ISSN
1755-148X (Electronic)
ISSN-L
1755-1471
Statut éditorial
Publié
Date de publication
10/2012
Peer-reviewed
Oui
Volume
25
Numéro
1
Pages
37-46
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Résumé
Melanoma antigen recognized by T cells 1 (MART-1) is a melanoma-specific antigen, which has been thoroughly studied in the context of immunotherapy against malignant melanoma and which is found only in the pigment cell lineage. However, its exact function and involvement in pigmentation is not clearly understood. Melanoma antigen recognized by T cells 1 has been shown to interact with the melanosomal proteins Pmel17 and OA1. To understand the function of MART-1 in pigmentation, we developed a new knockout mouse model. Mice deficient in MART-1 are viable, but loss of MART-1 leads to a coat color phenotype, with a reduction in total melanin content of the skin and hair. Lack of MART-1 did not affect localization of melanocyte-specific proteins nor maturation of Pmel17. Melanosomes of hair follicle melanocytes in MART-1 knockout mice displayed morphological abnormalities, which were exclusive to stage III and IV melanosomes. In conclusion, our results suggest that MART-1 is a pigmentation gene that is required for melanosome biogenesis and/or maintenance.
Mots-clé
Animals, Cells, Cultured/metabolism, Genetic Vectors, Hair/metabolism, Hair Color/genetics, MART-1 Antigen/genetics, MART-1 Antigen/physiology, Melanins/metabolism, Melanocytes/metabolism, Melanosomes/metabolism, Melanosomes/pathology, Mice, Mice, Inbred C57BL, Mice, Knockout, Phenotype, Skin/cytology, Skin/metabolism, gp100 Melanoma Antigen/metabolism
Pubmed
Web of science
Création de la notice
28/06/2012 18:58
Dernière modification de la notice
20/08/2019 15:19
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