Atrial, ventricular or both cannulation sites to optimize left ventricular assistance?

Details

Serval ID
serval:BIB_5FFE726B4BF2
Type
Inproceedings: an article in a conference proceedings.
Publication sub-type
Abstract (Abstract): shot summary in a article that contain essentials elements presented during a scientific conference, lecture or from a poster.
Collection
Publications
Institution
Title
Atrial, ventricular or both cannulation sites to optimize left ventricular assistance?
Title of the conference
46th Annual Conference of the American Society for Artificial Internal Organ (ASAIO)
Author(s)
Tevaearai H., Mueller X., Jegger D., Horisberger J., von Segesser L.K.
Address
New York, New York, United-States, June 28-July 1, 2000
ISBN
1058-2916
Publication state
Published
Issued date
2000
Peer-reviewed
Oui
Volume
46
Series
ASAIO Journal
Pages
173
Language
english
Abstract
The efficiency of left ventricular assist devices (LVAD) depends on the capacity of the inflow cannula to drain blood into the pump. Left atrial (LA) and left ventricular (LV) sites are compared in an animal model mimicking different hemodynamic situations. Three calves (56.3±5.0 kg) monitored with ECG, arterial pressure and central venous pressure (CVP) were equipped with a Thoratec LVAD used in fill-empty mode. A regular CPB pump was used as a RVAD (jugular vein/pulmonary artery). CVP was adjusted to defined preload conditions by storage (or perfusion) of blood into (or from) the venous reservoir. We compared the LA and LV inflow cannulation sites, used separately or simultaneously, on the output of the LVAD, tested alone on a beating heart, and with the CPB (BiVAD) on a beating then fibrillating heart. In every conditions, increase of CVP highlighted the differences of LVAD's performance due to the sites of inflow cannulation. For a CVP of 14 mmHG, LVAD used on a beating heart was better with the LV (4.5±0.4 l/min) as compared to the LA cannulation (3.9±0.4 l/min, p < 0.01). Results were similar with a BiVAD used on a beating heart (4.9±0.2 1/min for LV vs. 3.8±0.6 l/min for LA cannulation, p < 0.001). However, with a fibrillating heart, LA cannulation allowed better LVAD performance (2.9±0.3 vs. 2.4±0.1 l/min, p < 0.001). Using both LV and LA inflow cannulae simultaneously, did not improve the LVAD output in none of the situations. LV cannulation increases LVAD performance in beating hearts. However, because the fibrillating heart represents the extreme of a failing heart, the use of a LA site for inflow cannulation must be considered for a better BiVAD performance.
Keywords
Animals, Cattle, Heart Atria, Heart Failure/physiopathology, Heart Failure/surgery, Heart Ventricles, Heart-Assist Devices, Prosthesis Implantation, Ventricular Function, Left, Ventricular Function, Right
Create date
28/01/2008 9:28
Last modification date
20/08/2019 14:17
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