Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Details
Serval ID
serval:BIB_5F567D1EEB17
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Journal
Translational psychiatry
Publication state
Published
Issued date
01/2013
Volume
3
Pages
e216
Language
english
Abstract
Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression induced by peripubertal exposure to stress with face, construct and predictive validity. We show that male rats submitted to fear-induction experiences during the peripubertal period exhibit high and sustained rates of increased aggression at adulthood, even against unthreatening individuals, and increased testosterone/corticosterone ratio. They also exhibit hyperactivity in the amygdala under both basal conditions (evaluated by
Keywords
Animals, Gene Expression, Disease Models, Animal, Male, Aggression/physiology/*psychology, Amygdala/*physiopathology, Analysis of Variance, Clorgyline/therapeutic use, Conditioning, Psychological/physiology, Fear/physiology/*psychology, Immunohistochemistry, Monoamine Oxidase Inhibitors/therapeutic use, Monoamine Oxidase/drug effects/*genetics, Prefrontal Cortex/*physiopathology, Proto-Oncogene Proteins c-fos/analysis, Rats, Sexual Maturation/physiology, Stress, Psychological/complications/*genetics/physiopathology
Pubmed
Create date
19/02/2020 12:23
Last modification date
19/06/2020 5:26