Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.

Détails

ID Serval
serval:BIB_5F567D1EEB17
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Peripuberty stress leads to abnormal aggression, altered amygdala and orbitofrontal reactivity and increased prefrontal MAOA gene expression.
Périodique
Translational psychiatry
Auteur⸱e⸱s
Marquez C., Poirier G. L., Cordero M. I., Larsen M. H., Groner A., Marquis J., Magistretti P. J., Trono D., Sandi C.
Statut éditorial
Publié
Date de publication
01/2013
Volume
3
Pages
e216
Langue
anglais
Résumé
Although adverse early life experiences have been found to increase lifetime risk to develop violent behaviors, the neurobiological mechanisms underlying these long-term effects remain unclear. We present a novel animal model for pathological aggression induced by peripubertal exposure to stress with face, construct and predictive validity. We show that male rats submitted to fear-induction experiences during the peripubertal period exhibit high and sustained rates of increased aggression at adulthood, even against unthreatening individuals, and increased testosterone/corticosterone ratio. They also exhibit hyperactivity in the amygdala under both basal conditions (evaluated by
Mots-clé
Animals, Gene Expression, Disease Models, Animal, Male, Aggression/physiology/*psychology, Amygdala/*physiopathology, Analysis of Variance, Clorgyline/therapeutic use, Conditioning, Psychological/physiology, Fear/physiology/*psychology, Immunohistochemistry, Monoamine Oxidase Inhibitors/therapeutic use, Monoamine Oxidase/drug effects/*genetics, Prefrontal Cortex/*physiopathology, Proto-Oncogene Proteins c-fos/analysis, Rats, Sexual Maturation/physiology, Stress, Psychological/complications/*genetics/physiopathology
Pubmed
Création de la notice
19/02/2020 12:23
Dernière modification de la notice
19/06/2020 5:26
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