Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_5D2F26C48438
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand.
Journal
AIDS
Author(s)
Crisinel Pierre-Alex
Working group(s)
The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) study group
Contributor(s)
Chappell E., Turkova A., Goetghebuer T., Jackson C., Chiappini E., Galli L., Gingaras C., Spoulou V., Lisi C., Ansone S., Wolfs T., Marczynska M., Ene L., Plotnikova Y., Voronin E., Samarina A., Fortuny C., Navarro M.L., Tomas Ramos J., Navér L., Crisinel P.A., Jourdain G., Ngo-Giang-Huong N., Bailey H., Malyuta R., Volokha A., Bamford A., Crichton S., Foster C., Thorne C., Gibb D.M., Giaquinto C., Collins I.J., Judd A.
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Publication state
Published
Issued date
01/10/2021
Peer-reviewed
Oui
Volume
35
Number
12
Pages
1973-1985
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Investigate trends over time and predictors of malignancies among children and young people with HIV.
Pooled data from 17 cohorts in 15 countries across Europe and Thailand.
Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression.
Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis.
The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation.
Keywords
Acquired Immunodeficiency Syndrome, Adolescent, Adult, Aged, Child, Europe, Europe, Eastern, HIV Infections/complications, HIV Infections/diagnosis, HIV Infections/epidemiology, Humans, Infant, Newborn, Male, Neoplasms/epidemiology, Thailand
Pubmed
Open Access
Yes
Create date
04/10/2021 11:19
Last modification date
12/01/2022 7:10
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