Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand.
Détails
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_5D2F26C48438
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Malignancies among children and young people with HIV in Western and Eastern Europe and Thailand.
Périodique
AIDS
Collaborateur⸱rice⸱s
The European Pregnancy and Paediatric Infections Cohort Collaboration (EPPICC) study group
Contributeur⸱rice⸱s
Crisinel Pierre-Alex, Turkova A., Goetghebuer T., Jackson C., Chiappini E., Galli L., Gingaras C., Spoulou V., Lisi C., Ansone S., Wolfs T., Marczynska M., Ene L., Plotnikova Y., Voronin E., Samarina A., Fortuny C., Navarro M.L., Tomas Ramos J., Navér L., Crisinel P.A., Jourdain G., Ngo-Giang-Huong N., Bailey H., Malyuta R., Volokha A., Bamford A., Crichton S., Foster C., Thorne C., Gibb D.M., Giaquinto C., Collins I.J., Judd A.
ISSN
1473-5571 (Electronic)
ISSN-L
0269-9370
Statut éditorial
Publié
Date de publication
01/10/2021
Peer-reviewed
Oui
Volume
35
Numéro
12
Pages
1973-1985
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Investigate trends over time and predictors of malignancies among children and young people with HIV.
Pooled data from 17 cohorts in 15 countries across Europe and Thailand.
Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression.
Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis.
The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation.
Pooled data from 17 cohorts in 15 countries across Europe and Thailand.
Individuals diagnosed with HIV and presenting to paediatric care less than 18 years of age were included. Time at risk began at birth for children with documented vertically acquired HIV, and from first HIV-care visit for others. Children were followed until death, loss-to-follow-up, or last visit in paediatric or adult care (where data after transfer to adult care were available). Rates of reported malignancies were calculated overall and for AIDS-defining malignancies (ADM) and non-AIDS-defining malignancies (NADM) separately. Risk factors for any malignancy were explored using Poisson regression, and for mortality following a malignancy diagnosis using Cox regression.
Among 9632 individuals included, 140 (1.5%) were ever diagnosed with a malignancy, of which 112 (80%) were ADM. Overall, the rate of any malignancy was 1.18 per 1000 person-years; the rate of ADM decreased over time whereas the rate of NADM increased. Male sex, being from a European cohort, vertically acquired HIV, current severe immunosuppression, current viral load greater than 400 copies/ml, older age, and, for those not on treatment, earlier calendar year, were risk factors for a malignancy diagnosis. Fifty-eight (41%) individuals with a malignancy died, a median 2.4 months (IQR 0.6-8.8) after malignancy diagnosis.
The rate of ADM has declined since widespread availability of combination ART, although of NADM, there was a small increase. Mortality following a malignancy was high, warranting further investigation.
Mots-clé
Acquired Immunodeficiency Syndrome, Adolescent, Adult, Aged, Child, Europe, Europe, Eastern, HIV Infections/complications, HIV Infections/diagnosis, HIV Infections/epidemiology, Humans, Infant, Newborn, Male, Neoplasms/epidemiology, Thailand
Pubmed
Open Access
Oui
Création de la notice
04/10/2021 12:19
Dernière modification de la notice
29/05/2024 7:11