Article: article from journal or magazin.
In vivo localisation of radiolabelled monoclonal antibody in human gliomas.
British Journal of Neurosurgery
F(ab')2-fragments of the anti-melanoma monoclonal antibody MeI-14 were labelled with 123I for external scanning and with 125I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously 131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of 125I and 131I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.
Antibodies, Monoclonal/diagnostic use, Antibodies, Monoclonal/pharmacokinetics, Brain Neoplasms/immunology, Brain Neoplasms/radionuclide imaging, Glioma/immunology, Glioma/radionuclide imaging, Humans, Immunoglobulin Fab Fragments/diagnostic use, Immunoglobulin Fab Fragments/pharmacokinetics, Tomography, Emission-Computed/methods
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