In vivo localisation of radiolabelled monoclonal antibody in human gliomas.

Détails

ID Serval
serval:BIB_5C4DB3FA63E9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
In vivo localisation of radiolabelled monoclonal antibody in human gliomas.
Périodique
British Journal of Neurosurgery
Auteur(s)
Behnke J., Mach J.P., Buchegger F., Carrel S., Delaloye B., De Tribolet N.
ISSN
0268-8697 (Print)
ISSN-L
0268-8697
Statut éditorial
Publié
Date de publication
1988
Peer-reviewed
Oui
Volume
2
Numéro
2
Pages
193-197
Langue
anglais
Résumé
F(ab')2-fragments of the anti-melanoma monoclonal antibody MeI-14 were labelled with 123I for external scanning and with 125I for tissue measurement of radioactivity and injected intravenously into patients scheduled for surgical resection of a glioma. The paired-label study was performed by injecting simultaneously 131I-labelled control (F(ab')2-fragments. The patients were scanned by computerised tomoscintigraphy. After surgery, the activities of 125I and 131I were counted in tumour and normal tissues. The results indicate that there was a low but definite uptake of the antibody in the tumour due to its specificity. The external detection was difficult because of accumulation of antibody fragments in the skull.
Mots-clé
Antibodies, Monoclonal/diagnostic use, Antibodies, Monoclonal/pharmacokinetics, Brain Neoplasms/immunology, Brain Neoplasms/radionuclide imaging, Glioma/immunology, Glioma/radionuclide imaging, Humans, Immunoglobulin Fab Fragments/diagnostic use, Immunoglobulin Fab Fragments/pharmacokinetics, Tomography, Emission-Computed/methods
Pubmed
Création de la notice
25/01/2008 12:28
Dernière modification de la notice
20/08/2019 15:14
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