Cleft Lip and Palate Antenatal Diagnosis: A Swiss University Center Performance Analysis.
Details
Serval ID
serval:BIB_5B0EF1A30FA8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cleft Lip and Palate Antenatal Diagnosis: A Swiss University Center Performance Analysis.
Journal
Diagnostics
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Publication state
Published
Issued date
26/07/2023
Peer-reviewed
Oui
Volume
13
Number
15
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Abstract
Precision of cleft lip and/or palate antenatal diagnosis plays a significant role in counselling, neonatal care, surgical strategies and psychological support of the family. This study aims to measure the accuracy of antenatal diagnosis in our institution and the detection rate of cleft lip and/or palate on routine morphologic ultrasonography. In this retrospective observational study, we compared antenatal and postnatal diagnosis of 233 patients followed in our unit. We classified our patients according to the Kernahan and Stark's classification system: Group 1: facial cleft including labial and labio-maxillary clefts; Group 2: facial cleft including total, subtotal and submucous palatal clefts; Group 3: labio-maxillary-palatal clefts. Out of 233 patients, 104 were antenatally diagnosed with a facial cleft, i.e., an overall detection rate of 44.6%. The diagnosis was confirmed at birth in 65 of these patients, i.e., an overall accuracy of 62.5%. Of the 67 children (29.2%) in Group 1, the screening detection rate was 58.2% with an antenatal diagnostic accuracy of 48.7%. Of the 97 children (41.6%) in Group 2, the screening detection rate was 2% with an antenatal diagnostic accuracy of 50%. Of the 69 children (29.6%) in Group 3, the screening detection rate was 91.3% with an antenatal diagnostic accuracy of 71.4%. Our study demonstrates a relatively poor diagnostic accuracy in prenatal ultrasound, where the diagnosis was inaccurate in one third to one half of patients. It showed great variability in the screening detection rate depending on the diagnostic group observed, as well as a low rate of detection of palatal clefts.
Keywords
accuracy, cleft lip, cleft palate, detection rate, pregnancy, prenatal ultrasonography
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2023 8:18
Last modification date
08/08/2024 7:34