Cleft Lip and Palate Antenatal Diagnosis: A Swiss University Center Performance Analysis.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_5B0EF1A30FA8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cleft Lip and Palate Antenatal Diagnosis: A Swiss University Center Performance Analysis.
Périodique
Diagnostics
ISSN
2075-4418 (Print)
ISSN-L
2075-4418
Statut éditorial
Publié
Date de publication
26/07/2023
Peer-reviewed
Oui
Volume
13
Numéro
15
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Precision of cleft lip and/or palate antenatal diagnosis plays a significant role in counselling, neonatal care, surgical strategies and psychological support of the family. This study aims to measure the accuracy of antenatal diagnosis in our institution and the detection rate of cleft lip and/or palate on routine morphologic ultrasonography. In this retrospective observational study, we compared antenatal and postnatal diagnosis of 233 patients followed in our unit. We classified our patients according to the Kernahan and Stark's classification system: Group 1: facial cleft including labial and labio-maxillary clefts; Group 2: facial cleft including total, subtotal and submucous palatal clefts; Group 3: labio-maxillary-palatal clefts. Out of 233 patients, 104 were antenatally diagnosed with a facial cleft, i.e., an overall detection rate of 44.6%. The diagnosis was confirmed at birth in 65 of these patients, i.e., an overall accuracy of 62.5%. Of the 67 children (29.2%) in Group 1, the screening detection rate was 58.2% with an antenatal diagnostic accuracy of 48.7%. Of the 97 children (41.6%) in Group 2, the screening detection rate was 2% with an antenatal diagnostic accuracy of 50%. Of the 69 children (29.6%) in Group 3, the screening detection rate was 91.3% with an antenatal diagnostic accuracy of 71.4%. Our study demonstrates a relatively poor diagnostic accuracy in prenatal ultrasound, where the diagnosis was inaccurate in one third to one half of patients. It showed great variability in the screening detection rate depending on the diagnostic group observed, as well as a low rate of detection of palatal clefts.
Mots-clé
accuracy, cleft lip, cleft palate, detection rate, pregnancy, prenatal ultrasonography
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/08/2023 8:18
Dernière modification de la notice
08/08/2024 7:34