Article: article from journal or magazin.
Hypotensive effect of human factor XII active fragment in conscious normotensive rats: role of bradykinin.
Journal of Hypertension. Supplement
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the bradykinin-processing enzyme kininase II. These results therefore suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.
Animals, Blood Pressure, Bradykinin, Captopril, Dose-Response Relationship, Drug, Factor XII, Humans, Male, Peptide Fragments, Rats, Rats, Inbred Strains
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