Hypotensive effect of human factor XII active fragment in conscious normotensive rats: role of bradykinin.
Détails
ID Serval
serval:BIB_5AFA57C3B877
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Hypotensive effect of human factor XII active fragment in conscious normotensive rats: role of bradykinin.
Périodique
Journal of Hypertension. Supplement
ISSN
0952-1178
Statut éditorial
Publié
Date de publication
1984
Volume
2
Numéro
3
Pages
S341-342
Langue
anglais
Résumé
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the bradykinin-processing enzyme kininase II. These results therefore suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.
Mots-clé
Animals, Blood Pressure, Bradykinin, Captopril, Dose-Response Relationship, Drug, Factor XII, Humans, Male, Peptide Fragments, Rats, Rats, Inbred Strains
Pubmed
Création de la notice
25/01/2008 16:27
Dernière modification de la notice
20/08/2019 15:13
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