Hypotensive effect of human factor XII active fragment in conscious normotensive rats: role of bradykinin.

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Serval ID
serval:BIB_5AFA57C3B877
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Hypotensive effect of human factor XII active fragment in conscious normotensive rats: role of bradykinin.
Journal
Journal of Hypertension. Supplement
Author(s)
Waeber B., Nussberger J., Brunner H.R., de Agostini A., Schapira M.
ISSN
0952-1178
Publication state
Published
Issued date
1984
Volume
2
Number
3
Pages
S341-342
Language
english
Abstract
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the bradykinin-processing enzyme kininase II. These results therefore suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.
Keywords
Animals, Blood Pressure, Bradykinin, Captopril, Dose-Response Relationship, Drug, Factor XII, Humans, Male, Peptide Fragments, Rats, Rats, Inbred Strains
OAI-PMH
oai:serval.unil.ch:BIB_5AFA57C3B877
Pubmed
6400378
Create date
25/01/2008 15:27
Last modification date
20/08/2019 14:13
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