A fatal dothiepin overdose.
Details
Serval ID
serval:BIB_5A04814D8C41
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
A fatal dothiepin overdose.
Journal
Forensic Science International
ISSN
0379-0738[print], 0379-0738[linking]
Publication state
Published
Issued date
1995
Volume
76
Number
3
Pages
205-209
Language
english
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
High pressure liquid chromatography coupled to photodiode array detector and capillary gas chromatography coupled to mass spectrometry were employed to quantify dothiepin in biological fluids, tissues and hair in a death attributed to oral dothiepin (Prothiaden) ingestion. The blood concentration of dothiepin was 5.75 mg/l. Hair analysis clearly indicated a chronic antidepressant exposure, with a dothiepin concentration of 1.89 ng/mg hair. Results are discussed in the light of the existing literature.
Keywords
Adult, Antidepressive Agents, Tricyclic/analysis, Antidepressive Agents, Tricyclic/poisoning, Chromatography, High Pressure Liquid, Dothiepin/analysis, Dothiepin/poisoning, Fatal Outcome, Forensic Medicine/methods, Gas Chromatography-Mass Spectrometry, Hair/chemistry, Humans, Male, Poisoning/blood, Poisoning/diagnosis
Pubmed
Create date
19/10/2010 16:34
Last modification date
20/08/2019 15:13
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