The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.

Details

Serval ID
serval:BIB_58990692247E
Type
Article: article from journal or magazin.
Collection
Publications
Title
The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Lammertsma A.A., Frackowiak R.S., Hoffman J.M., Huang S.C., Weinberg I.N., Dahlbom M., MacDonald N.S., Hoffman E.J., Mazziotta J.C., Heather J.D.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1989
Volume
9
Number
4
Pages
461-470
Language
english
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Abstract
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.
Keywords
Adult, Brain/blood supply, Brain/metabolism, Carbon Radioisotopes/diagnostic use, Humans, Male, Oxygen Radioisotopes/diagnostic use, Regional Blood Flow, Tomography, Emission-Computed/methods, Water/metabolism
Pubmed
Web of science
Create date
08/10/2011 13:59
Last modification date
20/08/2019 14:12
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