Article: article from journal or magazin.
The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.
Journal of Cerebral Blood Flow and Metabolism
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.
Adult, Brain/blood supply, Brain/metabolism, Carbon Radioisotopes/diagnostic use, Humans, Male, Oxygen Radioisotopes/diagnostic use, Regional Blood Flow, Tomography, Emission-Computed/methods, Water/metabolism
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