The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.

Détails

ID Serval
serval:BIB_58990692247E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.
Périodique
Journal of Cerebral Blood Flow and Metabolism
Auteur(s)
Lammertsma A.A., Frackowiak R.S., Hoffman J.M., Huang S.C., Weinberg I.N., Dahlbom M., MacDonald N.S., Hoffman E.J., Mazziotta J.C., Heather J.D.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Statut éditorial
Publié
Date de publication
1989
Volume
9
Numéro
4
Pages
461-470
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.Publication Status: ppublish
Résumé
A new method to measure regional CBF (rCBF) and volume of distribution of water is presented. It centres on recording the tissue build-up and retention of 15O-labelled water during the continuous inhalation of 15O-labelled carbon dioxide. Simultaneously, the arterial concentration is continuously monitored, and corrections for delay and dispersion in the recorded response are made by curve fitting. The values for the volume of distribution of water obtained in four normal subjects were close to reported in vitro values. Using the same fixed distribution volumes for both build-up and steady-state studies resulted in comparable rCBF values for both techniques.
Mots-clé
Adult, Brain/blood supply, Brain/metabolism, Carbon Radioisotopes/diagnostic use, Humans, Male, Oxygen Radioisotopes/diagnostic use, Regional Blood Flow, Tomography, Emission-Computed/methods, Water/metabolism
Pubmed
Web of science
Création de la notice
08/10/2011 14:59
Dernière modification de la notice
20/08/2019 15:12
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