Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Vitale, I.; Pietrocola, F.; Guilbaud, E.; Aaronson, S.A.; Abrams, J.M.; Adam, D.; Agostini, M.; Agostinis, P.; Alnemri, E.S.; Altucci, L.; Amelio, I.; Andrews, D.W.; Aqeilan, R.I.; Arama, E.; Baehrecke, E.H.; Balachandran, S.; Bano, D.; Barlev, N.A.; Bartek, J.; Bazan, N.G.; Becker, C.; Bernassola, F.; Bertrand, MJM; Bianchi, M.E.; Blagosklonny, M.V.; Blander, J.M.; Blandino, G.; Blomgren, K.; Borner, C.; Bortner, C.D.; Bove, P.; Boya, P.; Brenner, C.; Broz, P.; Brunner, T.; Damgaard, R.B.; Calin, G.A.; Campanella, M.; Candi, E.; Carbone, M.; Carmona-Gutierrez, D.; Cecconi, F.; Chan, F.K.; Chen, G.Q.; Chen, Q.; Chen, Y.H.; Cheng, E.H.; Chipuk, J.E.; Cidlowski, J.A.; Ciechanover, A.; Ciliberto, G.; Conrad, M.; Cubillos-Ruiz, J.R.; Czabotar, P.E.; D'Angiolella, V.; Daugaard, M.; Dawson, T.M.; Dawson, V.L.; De Maria, R.; De Strooper, B.; Debatin, K.M.; Deberardinis, R.J.; Degterev, A.; Del Sal, G.; Deshmukh, M.; Di Virgilio, F.; Diederich, M.; Dixon, S.J.; Dynlacht, B.D.; El-Deiry, W.S.; Elrod, J.W.; Engeland, K.; Fimia, G.M.; Galassi, C.; Ganini, C.; Garcia-Saez, A.J.; Garg, A.D.; Garrido, C.; Gavathiotis, E.; Gerlic, M.; Ghosh, S.; Green, D.R.; Greene, L.A.; Gronemeyer, H.; Häcker, G.; Hajnóczky, G.; Hardwick, J.M.; Haupt, Y.; He, S.; Heery, D.M.; Hengartner, M.O.; Hetz, C.; Hildeman, D.A.; Ichijo, H.; Inoue, S.; Jäättelä, M.; Janic, A.; Joseph, B.; Jost, P.J.; Kanneganti, T.D.; Karin, M.; Kashkar, H.; Kaufmann, T.; Kelly, G.L.; Kepp, O.; Kimchi, A.; Kitsis, R.N.; Klionsky, D.J.; Kluck, R.; Krysko, D.V.; Kulms, D.; Kumar, S.; Lavandero, S.; Lavrik, I.N.; Lemasters, J.J.; Liccardi, G.; Linkermann, A.; Lipton, S.A.; Lockshin, R.A.; López-Otín, C.; Luedde, T.; MacFarlane, M.; Madeo, F.; Malorni, W.; Manic, G.; Mantovani, R.; Marchi, S.; Marine, J.C.; Martin, S.J.; Martinou, J.C.; Mastroberardino, P.G.; Medema, J.P.; Mehlen, P.; Meier, P.; Melino, G.; Melino, S.; Miao, E.A.; Moll, U.M.; Muñoz-Pinedo, C.; Murphy, D.J.; Niklison-Chirou, M.V.; Novelli, F.; Núñez, G.; Oberst, A.; Ofengeim, D.; Opferman, J.T.; Oren, M.; Pagano, M.; Panaretakis, T.; Pasparakis, M.; Penninger, J.M.; Pentimalli, F.; Pereira, D.M.; Pervaiz, S.; Peter, M.E.; Pinton, P.; Porta, G.; Prehn, JHM; Puthalakath, H.; Rabinovich, G.A.; Rajalingam, K.; Ravichandran, K.S.; Rehm, M.; Ricci, J.E.; Rizzuto, R.; Robinson, N.; Rodrigues, CMP; Rotblat, B.; Rothlin, C.V.; Rubinsztein, D.C.; Rudel, T.; Rufini, A.; Ryan, K.M.; Sarosiek, K.A.; Sawa, A.; Sayan, E.; Schroder, K.; Scorrano, L.; Sesti, F.; Shao, F.; Shi, Y.; Sica, G.S.; Silke, J.; Simon, H.U.; Sistigu, A.; Stephanou, A.; Stockwell, B.R.; Strapazzon, F.; Strasser, A.; Sun, L.; Sun, E.; Sun, Q.; Szabadkai, G.; Tait, SWG; Tang, D.; Tavernarakis, N.; Troy, C.M.; Turk, B.; Urbano, N.; Vandenabeele, P.; Vanden Berghe, T.; Vander Heiden, M.G.; Vanderluit, J.L.; Verkhratsky, A.; Villunger, A.; von Karstedt, S.; Voss, A.K.; Vousden, K.H.; Vucic, D.; Vuri, D.; Wagner, E.F.; Walczak, H.; Wallach, D.; Wang, R.; Wang, Y.; Weber, A.; Wood, W.; Yamazaki, T.; Yang, H.T.; Zakeri, Z.; Zawacka-Pankau, J.E.; Zhang, L.; Zhang, H.; Zhivotovsky, B.; Zhou, W.; Piacentini, M.; Kroemer, G.; Galluzzi, L.

doi:10.1038/s41418-023-01153-w

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Details

Request a copy Under indefinite embargo.
UNIL restricted access
State: Public
Version: author
License: Not specified

Serval ID

serval:BIB_5886312BEF39

Type

Article: article from journal or magazin.

Publication sub-type

Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.

Collection

Publications

Institution

UNIL/CHUV

Title

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Journal

Cell death and differentiation

Author(s)

Vitale I., Pietrocola F., Guilbaud E., Aaronson S.A., Abrams J.M., Adam D., Agostini M., Agostinis P., Alnemri E.S., Altucci L., Amelio I., Andrews D.W., Aqeilan R.I., Arama E., Baehrecke E.H., Balachandran S., Bano D., Barlev N.A., Bartek J., Bazan N.G., Becker C., Bernassola F., Bertrand MJM, Bianchi M.E., Blagosklonny M.V., Blander J.M., Blandino G., Blomgren K., Borner C., Bortner C.D., Bove P., Boya P., Brenner C., Broz P., Brunner T., Damgaard R.B., Calin G.A., Campanella M., Candi E., Carbone M., Carmona-Gutierrez D., Cecconi F., Chan F.K., Chen G.Q., Chen Q., Chen Y.H., Cheng E.H., Chipuk J.E., Cidlowski J.A., Ciechanover A., Ciliberto G., Conrad M., Cubillos-Ruiz J.R., Czabotar P.E., D'Angiolella V., Daugaard M., Dawson T.M., Dawson V.L., De Maria R., De Strooper B., Debatin K.M., Deberardinis R.J., Degterev A., Del Sal G., Deshmukh M., Di Virgilio F., Diederich M., Dixon S.J., Dynlacht B.D., El-Deiry W.S., Elrod J.W., Engeland K., Fimia G.M., Galassi C., Ganini C., Garcia-Saez A.J., Garg A.D., Garrido C., Gavathiotis E., Gerlic M., Ghosh S., Green D.R., Greene L.A., Gronemeyer H., Häcker G., Hajnóczky G., Hardwick J.M., Haupt Y., He S., Heery D.M., Hengartner M.O., Hetz C., Hildeman D.A., Ichijo H., Inoue S., Jäättelä M., Janic A., Joseph B., Jost P.J., Kanneganti T.D., Karin M., Kashkar H., Kaufmann T., Kelly G.L., Kepp O., Kimchi A., Kitsis R.N., Klionsky D.J., Kluck R., Krysko D.V., Kulms D., Kumar S., Lavandero S., Lavrik I.N., Lemasters J.J., Liccardi G., Linkermann A., Lipton S.A., Lockshin R.A., López-Otín C., Luedde T., MacFarlane M., Madeo F., Malorni W., Manic G., Mantovani R., Marchi S., Marine J.C., Martin S.J., Martinou J.C., Mastroberardino P.G., Medema J.P., Mehlen P., Meier P., Melino G., Melino S., Miao E.A., Moll U.M., Muñoz-Pinedo C., Murphy D.J., Niklison-Chirou M.V., Novelli F., Núñez G., Oberst A., Ofengeim D., Opferman J.T., Oren M., Pagano M., Panaretakis T., Pasparakis M., Penninger J.M., Pentimalli F., Pereira D.M., Pervaiz S., Peter M.E., Pinton P., Porta G., Prehn JHM, Puthalakath H., Rabinovich G.A., Rajalingam K., Ravichandran K.S., Rehm M., Ricci J.E., Rizzuto R., Robinson N., Rodrigues CMP, Rotblat B., Rothlin C.V., Rubinsztein D.C., Rudel T., Rufini A., Ryan K.M., Sarosiek K.A., Sawa A., Sayan E., Schroder K., Scorrano L., Sesti F., Shao F., Shi Y., Sica G.S., Silke J., Simon H.U., Sistigu A., Stephanou A., Stockwell B.R., Strapazzon F., Strasser A., Sun L., Sun E., Sun Q., Szabadkai G., Tait SWG, Tang D., Tavernarakis N., Troy C.M., Turk B., Urbano N., Vandenabeele P., Vanden Berghe T., Vander Heiden M.G., Vanderluit J.L., Verkhratsky A., Villunger A., von Karstedt S., Voss A.K., Vousden K.H., Vucic D., Vuri D., Wagner E.F., Walczak H., Wallach D., Wang R., Wang Y., Weber A., Wood W., Yamazaki T., Yang H.T., Zakeri Z., Zawacka-Pankau J.E., Zhang L., Zhang H., Zhivotovsky B., Zhou W., Piacentini M., Kroemer G., Galluzzi L.

ISSN

1476-5403 (Electronic)

ISSN-L

1350-9047

Publication state

Published

Issued date

05/2023

Peer-reviewed

Oui

Volume

Number

Pages

1097-1154

Language

english

Notes

Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Keywords

Animals, Humans, Apoptosis/genetics, Cell Death, Caspases/genetics, Caspases/metabolism, Carcinogenesis, Mammals/metabolism

OAI-PMH

oai:serval.unil.ch:BIB_5886312BEF39

DOI

10.1038/s41418-023-01153-w

Pubmed

37100955

Open Access

Yes

Create date

01/05/2023 7:36