Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Vitale, I.; Pietrocola, F.; Guilbaud, E.; Aaronson, S.A.; Abrams, J.M.; Adam, D.; Agostini, M.; Agostinis, P.; Alnemri, E.S.; Altucci, L.; Amelio, I.; Andrews, D.W.; Aqeilan, R.I.; Arama, E.; Baehrecke, E.H.; Balachandran, S.; Bano, D.; Barlev, N.A.; Bartek, J.; Bazan, N.G.; Becker, C.; Bernassola, F.; Bertrand, MJM; Bianchi, M.E.; Blagosklonny, M.V.; Blander, J.M.; Blandino, G.; Blomgren, K.; Borner, C.; Bortner, C.D.; Bove, P.; Boya, P.; Brenner, C.; Broz, P.; Brunner, T.; Damgaard, R.B.; Calin, G.A.; Campanella, M.; Candi, E.; Carbone, M.; Carmona-Gutierrez, D.; Cecconi, F.; Chan, F.K.; Chen, G.Q.; Chen, Q.; Chen, Y.H.; Cheng, E.H.; Chipuk, J.E.; Cidlowski, J.A.; Ciechanover, A.; Ciliberto, G.; Conrad, M.; Cubillos-Ruiz, J.R.; Czabotar, P.E.; D'Angiolella, V.; Daugaard, M.; Dawson, T.M.; Dawson, V.L.; De Maria, R.; De Strooper, B.; Debatin, K.M.; Deberardinis, R.J.; Degterev, A.; Del Sal, G.; Deshmukh, M.; Di Virgilio, F.; Diederich, M.; Dixon, S.J.; Dynlacht, B.D.; El-Deiry, W.S.; Elrod, J.W.; Engeland, K.; Fimia, G.M.; Galassi, C.; Ganini, C.; Garcia-Saez, A.J.; Garg, A.D.; Garrido, C.; Gavathiotis, E.; Gerlic, M.; Ghosh, S.; Green, D.R.; Greene, L.A.; Gronemeyer, H.; Häcker, G.; Hajnóczky, G.; Hardwick, J.M.; Haupt, Y.; He, S.; Heery, D.M.; Hengartner, M.O.; Hetz, C.; Hildeman, D.A.; Ichijo, H.; Inoue, S.; Jäättelä, M.; Janic, A.; Joseph, B.; Jost, P.J.; Kanneganti, T.D.; Karin, M.; Kashkar, H.; Kaufmann, T.; Kelly, G.L.; Kepp, O.; Kimchi, A.; Kitsis, R.N.; Klionsky, D.J.; Kluck, R.; Krysko, D.V.; Kulms, D.; Kumar, S.; Lavandero, S.; Lavrik, I.N.; Lemasters, J.J.; Liccardi, G.; Linkermann, A.; Lipton, S.A.; Lockshin, R.A.; López-Otín, C.; Luedde, T.; MacFarlane, M.; Madeo, F.; Malorni, W.; Manic, G.; Mantovani, R.; Marchi, S.; Marine, J.C.; Martin, S.J.; Martinou, J.C.; Mastroberardino, P.G.; Medema, J.P.; Mehlen, P.; Meier, P.; Melino, G.; Melino, S.; Miao, E.A.; Moll, U.M.; Muñoz-Pinedo, C.; Murphy, D.J.; Niklison-Chirou, M.V.; Novelli, F.; Núñez, G.; Oberst, A.; Ofengeim, D.; Opferman, J.T.; Oren, M.; Pagano, M.; Panaretakis, T.; Pasparakis, M.; Penninger, J.M.; Pentimalli, F.; Pereira, D.M.; Pervaiz, S.; Peter, M.E.; Pinton, P.; Porta, G.; Prehn, JHM; Puthalakath, H.; Rabinovich, G.A.; Rajalingam, K.; Ravichandran, K.S.; Rehm, M.; Ricci, J.E.; Rizzuto, R.; Robinson, N.; Rodrigues, CMP; Rotblat, B.; Rothlin, C.V.; Rubinsztein, D.C.; Rudel, T.; Rufini, A.; Ryan, K.M.; Sarosiek, K.A.; Sawa, A.; Sayan, E.; Schroder, K.; Scorrano, L.; Sesti, F.; Shao, F.; Shi, Y.; Sica, G.S.; Silke, J.; Simon, H.U.; Sistigu, A.; Stephanou, A.; Stockwell, B.R.; Strapazzon, F.; Strasser, A.; Sun, L.; Sun, E.; Sun, Q.; Szabadkai, G.; Tait, SWG; Tang, D.; Tavernarakis, N.; Troy, C.M.; Turk, B.; Urbano, N.; Vandenabeele, P.; Vanden Berghe, T.; Vander Heiden, M.G.; Vanderluit, J.L.; Verkhratsky, A.; Villunger, A.; von Karstedt, S.; Voss, A.K.; Vousden, K.H.; Vucic, D.; Vuri, D.; Wagner, E.F.; Walczak, H.; Wallach, D.; Wang, R.; Wang, Y.; Weber, A.; Wood, W.; Yamazaki, T.; Yang, H.T.; Zakeri, Z.; Zawacka-Pankau, J.E.; Zhang, L.; Zhang, H.; Zhivotovsky, B.; Zhou, W.; Piacentini, M.; Kroemer, G.; Galluzzi, L.

doi:10.1038/s41418-023-01153-w

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Détails

Demande d'une copie Sous embargo indéterminé.
Accès restreint UNIL
Etat: Public
Version: de l'auteur⸱e
Licence: Non spécifiée

ID Serval

serval:BIB_5886312BEF39

Type

Article: article d'un périodique ou d'un magazine.

Sous-type

Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.

Collection

Publications

Institution

UNIL/CHUV

Titre

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Périodique

Cell death and differentiation

Auteur⸱e⸱s

Vitale I., Pietrocola F., Guilbaud E., Aaronson S.A., Abrams J.M., Adam D., Agostini M., Agostinis P., Alnemri E.S., Altucci L., Amelio I., Andrews D.W., Aqeilan R.I., Arama E., Baehrecke E.H., Balachandran S., Bano D., Barlev N.A., Bartek J., Bazan N.G., Becker C., Bernassola F., Bertrand MJM, Bianchi M.E., Blagosklonny M.V., Blander J.M., Blandino G., Blomgren K., Borner C., Bortner C.D., Bove P., Boya P., Brenner C., Broz P., Brunner T., Damgaard R.B., Calin G.A., Campanella M., Candi E., Carbone M., Carmona-Gutierrez D., Cecconi F., Chan F.K., Chen G.Q., Chen Q., Chen Y.H., Cheng E.H., Chipuk J.E., Cidlowski J.A., Ciechanover A., Ciliberto G., Conrad M., Cubillos-Ruiz J.R., Czabotar P.E., D'Angiolella V., Daugaard M., Dawson T.M., Dawson V.L., De Maria R., De Strooper B., Debatin K.M., Deberardinis R.J., Degterev A., Del Sal G., Deshmukh M., Di Virgilio F., Diederich M., Dixon S.J., Dynlacht B.D., El-Deiry W.S., Elrod J.W., Engeland K., Fimia G.M., Galassi C., Ganini C., Garcia-Saez A.J., Garg A.D., Garrido C., Gavathiotis E., Gerlic M., Ghosh S., Green D.R., Greene L.A., Gronemeyer H., Häcker G., Hajnóczky G., Hardwick J.M., Haupt Y., He S., Heery D.M., Hengartner M.O., Hetz C., Hildeman D.A., Ichijo H., Inoue S., Jäättelä M., Janic A., Joseph B., Jost P.J., Kanneganti T.D., Karin M., Kashkar H., Kaufmann T., Kelly G.L., Kepp O., Kimchi A., Kitsis R.N., Klionsky D.J., Kluck R., Krysko D.V., Kulms D., Kumar S., Lavandero S., Lavrik I.N., Lemasters J.J., Liccardi G., Linkermann A., Lipton S.A., Lockshin R.A., López-Otín C., Luedde T., MacFarlane M., Madeo F., Malorni W., Manic G., Mantovani R., Marchi S., Marine J.C., Martin S.J., Martinou J.C., Mastroberardino P.G., Medema J.P., Mehlen P., Meier P., Melino G., Melino S., Miao E.A., Moll U.M., Muñoz-Pinedo C., Murphy D.J., Niklison-Chirou M.V., Novelli F., Núñez G., Oberst A., Ofengeim D., Opferman J.T., Oren M., Pagano M., Panaretakis T., Pasparakis M., Penninger J.M., Pentimalli F., Pereira D.M., Pervaiz S., Peter M.E., Pinton P., Porta G., Prehn JHM, Puthalakath H., Rabinovich G.A., Rajalingam K., Ravichandran K.S., Rehm M., Ricci J.E., Rizzuto R., Robinson N., Rodrigues CMP, Rotblat B., Rothlin C.V., Rubinsztein D.C., Rudel T., Rufini A., Ryan K.M., Sarosiek K.A., Sawa A., Sayan E., Schroder K., Scorrano L., Sesti F., Shao F., Shi Y., Sica G.S., Silke J., Simon H.U., Sistigu A., Stephanou A., Stockwell B.R., Strapazzon F., Strasser A., Sun L., Sun E., Sun Q., Szabadkai G., Tait SWG, Tang D., Tavernarakis N., Troy C.M., Turk B., Urbano N., Vandenabeele P., Vanden Berghe T., Vander Heiden M.G., Vanderluit J.L., Verkhratsky A., Villunger A., von Karstedt S., Voss A.K., Vousden K.H., Vucic D., Vuri D., Wagner E.F., Walczak H., Wallach D., Wang R., Wang Y., Weber A., Wood W., Yamazaki T., Yang H.T., Zakeri Z., Zawacka-Pankau J.E., Zhang L., Zhang H., Zhivotovsky B., Zhou W., Piacentini M., Kroemer G., Galluzzi L.

ISSN

1476-5403 (Electronic)

ISSN-L

1350-9047

Statut éditorial

Publié

Date de publication

05/2023

Peer-reviewed

Oui

Volume

Numéro

Pages

1097-1154

Langue

anglais

Notes

Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish

Résumé

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Mots-clé

Animals, Humans, Apoptosis/genetics, Cell Death, Caspases/genetics, Caspases/metabolism, Carcinogenesis, Mammals/metabolism

OAI-PMH

oai:serval.unil.ch:BIB_5886312BEF39

DOI

10.1038/s41418-023-01153-w

Pubmed

37100955

Open Access

Oui

Création de la notice

01/05/2023 7:36