Apoptotic cell death in disease-Current understanding of the NCCD 2023.
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UNIL restricted access
State: Public
Version: author
License: Not specified
Serval ID
serval:BIB_5886312BEF39
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Apoptotic cell death in disease-Current understanding of the NCCD 2023.
Journal
Cell death and differentiation
ISSN
1476-5403 (Electronic)
ISSN-L
1350-9047
Publication state
Published
Issued date
05/2023
Peer-reviewed
Oui
Volume
30
Number
5
Pages
1097-1154
Language
english
Notes
Publication types: Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Publication Status: ppublish
Abstract
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.
Keywords
Animals, Humans, Apoptosis/genetics, Cell Death, Caspases/genetics, Caspases/metabolism, Carcinogenesis, Mammals/metabolism
Pubmed
Open Access
Yes
Create date
01/05/2023 8:36
Last modification date
11/08/2023 6:58