On the applicability of a haplotype map to un-assayed populations

Details

Serval ID
serval:BIB_588462467D60
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
On the applicability of a haplotype map to un-assayed populations
Journal
Human Genetics
Author(s)
Pe'er  I., Beckmann  J. S.
ISSN
0340-6717 (Print)
Publication state
Published
Issued date
01/2004
Volume
114
Number
2
Pages
214-7
Notes
Letter
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Abstract
The rationale for mapping all common haplotypes in our species relies on reports of the conservation of haplotype blocks across human populations. Recent findings indicate that these blocks may, at least in part, be a random artifact of genetic drift. This raises the concern that the latter process may challenge the general applicability of a human haplotype map to case-by-case population-specific association studies. We develop arguments indicating that even stochastic drift-originated blocks will, under many conditions, be shared across populations, supporting the utilization of a panhuman haplotype map.
Keywords
Alleles Chromosome Mapping Computational Biology *Genetic Drift *Genetics, Population *Genome, Human Genotype *Haplotypes Humans Linkage Disequilibrium Models, Genetic *Polymorphism, Single Nucleotide *Variation (Genetics)
Pubmed
Web of science
Create date
25/01/2008 17:18
Last modification date
20/08/2019 15:12
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