On the applicability of a haplotype map to un-assayed populations

Détails

ID Serval
serval:BIB_588462467D60
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
On the applicability of a haplotype map to un-assayed populations
Périodique
Human Genetics
Auteur⸱e⸱s
Pe'er  I., Beckmann  J. S.
ISSN
0340-6717 (Print)
Statut éditorial
Publié
Date de publication
01/2004
Volume
114
Numéro
2
Pages
214-7
Notes
Letter
Research Support, Non-U.S. Gov't
Review --- Old month value: Jan
Résumé
The rationale for mapping all common haplotypes in our species relies on reports of the conservation of haplotype blocks across human populations. Recent findings indicate that these blocks may, at least in part, be a random artifact of genetic drift. This raises the concern that the latter process may challenge the general applicability of a human haplotype map to case-by-case population-specific association studies. We develop arguments indicating that even stochastic drift-originated blocks will, under many conditions, be shared across populations, supporting the utilization of a panhuman haplotype map.
Mots-clé
Alleles Chromosome Mapping Computational Biology *Genetic Drift *Genetics, Population *Genome, Human Genotype *Haplotypes Humans Linkage Disequilibrium Models, Genetic *Polymorphism, Single Nucleotide *Variation (Genetics)
Pubmed
Web of science
Création de la notice
25/01/2008 17:18
Dernière modification de la notice
20/08/2019 15:12
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