Midline long peripheral venous catheters are an interesting alternative to central venous catheters and PICC-lines when the placement of a peripheral venous catheter is impossible or when the patient requires prolonged intravenous treatment. Midline catheters can be inserted at the patient's bedside and require no radiological verification after insertion. They can be kept in place for up to 14 days and allow for repeated blood sampling. The mechanical, infectious, or thrombotic complications and safety profile do not differ from other venous catheters, notably PICC-line.