A-kinase anchoring proteins: scaffolding proteins in the heart.

Details

Serval ID
serval:BIB_551F486FF89B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
A-kinase anchoring proteins: scaffolding proteins in the heart.
Journal
American Journal of Physiology. Heart and Circulatory Physiology
Author(s)
Diviani D., Dodge-Kafka K.L., Li J., Kapiloff M.S.
ISSN
1522-1539 (Electronic)
ISSN-L
0363-6135
Publication state
Published
Issued date
2011
Volume
301
Number
5
Pages
H1742-H1753
Language
english
Abstract
The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called "A-kinase anchoring proteins" (AKAPs). In this review, we discuss recent advances in our understanding of how PKA is compartmentalized within the cardiac myocyte by AKAPs and how AKAP complexes modulate cardiac function in both health and disease.
Keywords
A Kinase Anchor Proteins/metabolism, Animals, Cardiovascular Agents/therapeutic use, Cyclic AMP/metabolism, Cyclic AMP-Dependent Protein Kinases/metabolism, Heart Diseases/drug therapy, Heart Diseases/enzymology, Humans, Myocardium/enzymology, Second Messenger Systems/drug effects
Pubmed
Web of science
Create date
08/12/2011 11:45
Last modification date
20/10/2020 10:12
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