A-kinase anchoring proteins: scaffolding proteins in the heart.

Détails

ID Serval
serval:BIB_551F486FF89B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
A-kinase anchoring proteins: scaffolding proteins in the heart.
Périodique
American Journal of Physiology. Heart and Circulatory Physiology
Auteur⸱e⸱s
Diviani D., Dodge-Kafka K.L., Li J., Kapiloff M.S.
ISSN
1522-1539 (Electronic)
ISSN-L
0363-6135
Statut éditorial
Publié
Date de publication
2011
Volume
301
Numéro
5
Pages
H1742-H1753
Langue
anglais
Résumé
The pleiotropic cyclic nucleotide cAMP is the primary second messenger responsible for autonomic regulation of cardiac inotropy, chronotropy, and lusitropy. Under conditions of prolonged catecholaminergic stimulation, cAMP also contributes to the induction of both cardiac myocyte hypertrophy and apoptosis. The formation of localized, multiprotein complexes that contain different combinations of cAMP effectors and regulatory enzymes provides the architectural infrastructure for the specialization of the cAMP signaling network. Scaffolds that bind protein kinase A are called "A-kinase anchoring proteins" (AKAPs). In this review, we discuss recent advances in our understanding of how PKA is compartmentalized within the cardiac myocyte by AKAPs and how AKAP complexes modulate cardiac function in both health and disease.
Mots-clé
A Kinase Anchor Proteins/metabolism, Animals, Cardiovascular Agents/therapeutic use, Cyclic AMP/metabolism, Cyclic AMP-Dependent Protein Kinases/metabolism, Heart Diseases/drug therapy, Heart Diseases/enzymology, Humans, Myocardium/enzymology, Second Messenger Systems/drug effects
Pubmed
Web of science
Création de la notice
08/12/2011 11:45
Dernière modification de la notice
20/10/2020 10:12
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