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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Journal of Experimental Medicine
Date de publication
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
Amino Acid Sequence, Animals, B-Cell Activating Factor, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Base Sequence, Cell Division, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 13/genetics, Cloning, Molecular, DNA Primers/genetics, Dendritic Cells/immunology, Humans, Ligands, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Molecular Sequence Data, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/physiology, Sequence Homology, Amino Acid, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/physiology
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