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BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Journal of Experimental Medicine
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
Amino Acid Sequence, Animals, B-Cell Activating Factor, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Base Sequence, Cell Division, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 13/genetics, Cloning, Molecular, DNA Primers/genetics, Dendritic Cells/immunology, Humans, Ligands, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Molecular Sequence Data, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/physiology, Sequence Homology, Amino Acid, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/physiology
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