BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_53CE7E893D3E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth.
Périodique
Journal of Experimental Medicine
Auteur(s)
Schneider P., MacKay F., Steiner V., Hofmann K., Bodmer J.L., Holler N., Ambrose C., Lawton P., Bixler S., Acha-Orbea H., Valmori D., Romero P., Werner-Favre C., Zubler R.H., Browning J.L., Tschopp J.
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1999
Volume
189
Numéro
11
Pages
1747-1756
Langue
anglais
Résumé
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family, designated BAFF (for B cell activating factor belonging to the TNF family), which is expressed by T cells and dendritic cells. Human BAFF was mapped to chromosome 13q32-34. Membrane-bound BAFF was processed and secreted through the action of a protease whose specificity matches that of the furin family of proprotein convertases. The expression of BAFF receptor appeared to be restricted to B cells. Both membrane-bound and soluble BAFF induced proliferation of anti-immunoglobulin M-stimulated peripheral blood B lymphocytes. Moreover, increased amounts of immunoglobulins were found in supernatants of germinal center-like B cells costimulated with BAFF. These results suggest that BAFF plays an important role as costimulator of B cell proliferation and function.
Mots-clé
Amino Acid Sequence, Animals, B-Cell Activating Factor, B-Lymphocytes/cytology, B-Lymphocytes/immunology, Base Sequence, Cell Division, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 13/genetics, Cloning, Molecular, DNA Primers/genetics, Dendritic Cells/immunology, Humans, Ligands, Lymphocyte Activation, Membrane Proteins/genetics, Membrane Proteins/physiology, Mice, Molecular Sequence Data, Receptors, Tumor Necrosis Factor/genetics, Receptors, Tumor Necrosis Factor/physiology, Sequence Homology, Amino Acid, T-Lymphocytes/immunology, Tumor Necrosis Factor-alpha/genetics, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 12:28
Dernière modification de la notice
20/08/2019 15:08
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