Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Details
State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_518F514F74D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Journal
Nature Neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
18
Number
3
Pages
376-378
Language
english
Abstract
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
Keywords
Animals, Cocaine/pharmacology, Conditioning, Operant/drug effects, Conditioning, Operant/physiology, Dopamine Uptake Inhibitors/pharmacology, Electric Stimulation, Excitatory Postsynaptic Potentials/drug effects, Excitatory Postsynaptic Potentials/physiology, Green Fluorescent Proteins/genetics, Green Fluorescent Proteins/metabolism, Habenula/cytology, Habenula/drug effects, Habenula/metabolism, Hindlimb Suspension, In Vitro Techniques, Luminescent Proteins/genetics, Luminescent Proteins/metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity/drug effects, Mutation/genetics, Patch-Clamp Techniques, Protein Transport/drug effects, Receptors, AMPA/genetics, Receptors, AMPA/metabolism, Swimming/psychology
Pubmed
Web of science
Create date
31/01/2017 11:30
Last modification date
20/08/2019 14:07
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