Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Détails
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_518F514F74D0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.
Périodique
Nature Neuroscience
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
18
Numéro
3
Pages
376-378
Langue
anglais
Résumé
Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.
Mots-clé
Animals, Cocaine/pharmacology, Conditioning, Operant/drug effects, Conditioning, Operant/physiology, Dopamine Uptake Inhibitors/pharmacology, Electric Stimulation, Excitatory Postsynaptic Potentials/drug effects, Excitatory Postsynaptic Potentials/physiology, Green Fluorescent Proteins/genetics, Green Fluorescent Proteins/metabolism, Habenula/cytology, Habenula/drug effects, Habenula/metabolism, Hindlimb Suspension, In Vitro Techniques, Luminescent Proteins/genetics, Luminescent Proteins/metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity/drug effects, Mutation/genetics, Patch-Clamp Techniques, Protein Transport/drug effects, Receptors, AMPA/genetics, Receptors, AMPA/metabolism, Swimming/psychology
Pubmed
Web of science
Création de la notice
31/01/2017 12:30
Dernière modification de la notice
20/08/2019 15:07
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