Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.

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Serval ID
serval:BIB_516406B5E329
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Journal
Bioorganic and Medicinal Chemistry
Author(s)
Bello C., Dal Bello G., Cea M., Nahimana A., Aubry D., Garuti A., Motta G., Moran E., Fruscione F., Pronzato P., Grossi F., Patrone F., Ballestrero A., Dupuis M., Sordat B., Zimmermann K., Loretan J., Wartmann M., Duchosal M.A., Nencioni A., Vogel P.
ISSN
1464-3391 (Electronic)
ISSN-L
0968-0896
Publication state
Published
Issued date
2011
Volume
19
Number
24
Pages
7720-7727
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.
OAI-PMH
oai:serval.unil.ch:BIB_516406B5E329
DOI
10.1016/j.bmc.2011.07.053
Pubmed
22079865
Web of science
000297860100044
Create date
24/02/2012 11:23
Last modification date
20/08/2019 15:07
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