Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.

Détails

ID Serval
serval:BIB_516406B5E329
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Périodique
Bioorganic and Medicinal Chemistry
Auteur⸱e⸱s
Bello C., Dal Bello G., Cea M., Nahimana A., Aubry D., Garuti A., Motta G., Moran E., Fruscione F., Pronzato P., Grossi F., Patrone F., Ballestrero A., Dupuis M., Sordat B., Zimmermann K., Loretan J., Wartmann M., Duchosal M.A., Nencioni A., Vogel P.
ISSN
1464-3391 (Electronic)
ISSN-L
0968-0896
Statut éditorial
Publié
Date de publication
2011
Volume
19
Numéro
24
Pages
7720-7727
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.
Pubmed
Web of science
Création de la notice
24/02/2012 10:23
Dernière modification de la notice
20/08/2019 14:07
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