Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Details
Serval ID
serval:BIB_516406B5E329
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Anti-cancer activity of 5-O-alkyl 1,4-imino-1,4-dideoxyribitols.
Journal
Bioorganic and Medicinal Chemistry
ISSN
1464-3391 (Electronic)
ISSN-L
0968-0896
Publication state
Published
Issued date
2011
Volume
19
Number
24
Pages
7720-7727
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
New derivatives of 1,4-dideoxy-1,4-imino-D-ribitol have been prepared and evaluated for their cytotoxicity on solid and haematological malignancies. 1,4-Dideoxy-5-O-[(9Z)-octadec-9-en-1-yl]-1,4-imino-D-ribitol (13, IC(50) ∼2 μM) and its C(18)-analogues (IC(50) <10 μM) are cytotoxic toward SKBR3 (breast cancer) cells. 13 also inhibits (IC(50) ∼8 μM) growth of JURKAT cells.
Pubmed
Web of science
Create date
24/02/2012 10:23
Last modification date
20/08/2019 14:07