The molecular architecture of the TNF superfamily.

Détails

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Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_5073D64C283D
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The molecular architecture of the TNF superfamily.
Périodique
Trends in Biochemical Sciences
Auteur(s)
Bodmer J.L., Schneider P., Tschopp J.
ISSN
0968-0004 (Print)
ISSN-L
0968-0004
Statut éditorial
Publié
Date de publication
2002
Volume
27
Numéro
1
Pages
19-26
Langue
anglais
Résumé
Ligands of the TNF (tumour necrosis factor) superfamily have pivotal roles in the organization and function of the immune system, and are implicated in the aetiology of several acquired and genetic diseases. TNF ligands share a common structural motif, the TNF homology domain (THD), which binds to cysteine-rich domains (CRDs) of TNF receptors. CRDs are composed of structural modules, whose variation in number and type confers heterogeneity upon the family. Protein folds reminiscent of the THD and CRD are also found in other protein families, raising the possibility that the mode of interaction between TNF and TNF receptors might be conserved in other contexts.
Mots-clé
Amino Acid Sequence, Ligands, Macromolecular Substances, Molecular Sequence Data, Molecular Structure, Protein Conformation, Protein Folding, Receptors, Tumor Necrosis Factor/chemistry, Sequence Homology, Amino Acid, Tumor Necrosis Factor-alpha/chemistry
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
08/05/2019 18:31
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