Article: article from journal or magazin.
Genetic variation in EEG activity during sleep in inbred mice.
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
4 Pt 2
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of the EEG in six inbred mice strains. Mean spectral EEG profiles (0-25 Hz) over 24 h were obtained for paradoxical sleep (PS), slow-wave sleep (SWS), and wakefulness. A highly significant genotype-specific variation was found for theta peak frequency during both PS and SWS, which strongly suggests the presence of a gene with a major effect. The strain distribution of theta peak frequency during exploratory behavior differed from that during sleep. In SWS, the relative contributions of delta (1-4 Hz) and sigma (11-15) power to the EEG varied with genotype and power in both frequency bands was negatively correlated. In addition, the EEG dynamics at state transitions were analyzed with a 4-s resolution. The onset of PS, but not that of wakefulness, was preceded by a pronounced peak in high-frequency (>11 Hz) power. These findings are discussed in terms of the neurophysiological mechanisms underlying rhythm generation and their control and modulation by the brain stem reticular-activating system.
Animals, Brain/physiology, Electroencephalography, Male, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains/physiology, Sleep/genetics, Sleep/physiology, Species Specificity
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