Genetic variation in EEG activity during sleep in inbred mice.
Détails
ID Serval
serval:BIB_4F7F2F2D24E4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genetic variation in EEG activity during sleep in inbred mice.
Périodique
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
ISSN
0363-6119
Statut éditorial
Publié
Date de publication
1998
Volume
275
Numéro
4 Pt 2
Pages
R1127-R1137
Langue
anglais
Résumé
The genetic variation in spontaneous rhythmic electroencephalographic (EEG) activity was assessed by the quantitative analysis of the EEG in six inbred mice strains. Mean spectral EEG profiles (0-25 Hz) over 24 h were obtained for paradoxical sleep (PS), slow-wave sleep (SWS), and wakefulness. A highly significant genotype-specific variation was found for theta peak frequency during both PS and SWS, which strongly suggests the presence of a gene with a major effect. The strain distribution of theta peak frequency during exploratory behavior differed from that during sleep. In SWS, the relative contributions of delta (1-4 Hz) and sigma (11-15) power to the EEG varied with genotype and power in both frequency bands was negatively correlated. In addition, the EEG dynamics at state transitions were analyzed with a 4-s resolution. The onset of PS, but not that of wakefulness, was preceded by a pronounced peak in high-frequency (>11 Hz) power. These findings are discussed in terms of the neurophysiological mechanisms underlying rhythm generation and their control and modulation by the brain stem reticular-activating system.
Mots-clé
Animals, Brain/physiology, Electroencephalography, Male, Mice, Mice, Inbred AKR, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred DBA, Mice, Inbred Strains/physiology, Sleep/genetics, Sleep/physiology, Species Specificity
Pubmed
Web of science
Création de la notice
24/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:05