APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
Details
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_4D2F3D6E5271
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
Journal
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Publication state
Published
Issued date
1998
Volume
188
Number
6
Pages
1185-1190
Language
english
Abstract
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.
Keywords
3T3 Cells, Amino Acid Sequence, Animals, Cell Division/drug effects, Growth Substances/physiology, Humans, Ligands, Lymphoma, B-Cell, Membrane Proteins/biosynthesis, Membrane Proteins/genetics, Mice, Mice, Inbred BALB C, Mice, Nude, Molecular Sequence Data, Neoplasm Transplantation, RNA, Messenger/biosynthesis, Transfection, Tumor Cells, Cultured/drug effects, Tumor Cells, Cultured/metabolism, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:18
Last modification date
20/08/2019 15:01