APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
Détails
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_4D2F3D6E5271
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth.
Périodique
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
ISSN-L
0022-1007
Statut éditorial
Publié
Date de publication
1998
Volume
188
Numéro
6
Pages
1185-1190
Langue
anglais
Résumé
Members of the tumor necrosis factor (TNF) family induce pleiotropic biological responses, including cell growth, differentiation, and even death. Here we describe a novel member of the TNF family designated APRIL (for a proliferation-inducing ligand). Although transcripts of APRIL are of low abundance in normal tissues, high levels of mRNA are detected in transformed cell lines, and in human cancers of colon, thyroid, and lymphoid tissues in vivo. The addition of recombinant APRIL to various tumor cells stimulates their proliferation. Moreover, APRIL-transfected NIH-3T3 cells show an increased rate of tumor growth in nude mice compared with the parental cell line. These findings suggest that APRIL may be implicated in the regulation of tumor cell growth.
Mots-clé
3T3 Cells, Amino Acid Sequence, Animals, Cell Division/drug effects, Growth Substances/physiology, Humans, Ligands, Lymphoma, B-Cell, Membrane Proteins/biosynthesis, Membrane Proteins/genetics, Mice, Mice, Inbred BALB C, Mice, Nude, Molecular Sequence Data, Neoplasm Transplantation, RNA, Messenger/biosynthesis, Transfection, Tumor Cells, Cultured/drug effects, Tumor Cells, Cultured/metabolism, Tumor Necrosis Factor Ligand Superfamily Member 13, Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:18
Dernière modification de la notice
20/08/2019 15:01