Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis
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Version: author
State: Public
Version: author
Serval ID
serval:BIB_4C55C8B1D132
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis
Journal
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Publication state
Published
Issued date
12/1996
Volume
184
Number
6
Pages
2109-17
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 1
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 1
Abstract
The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial gamma delta T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that gamma delta T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process.
Keywords
*Antigens, CD95
*Apoptosis
Arthritis, Infectious/*immunology
Borrelia burgdorferi Group/*immunology
CD4-Positive T-Lymphocytes/*immunology/microbiology
CD8-Positive T-Lymphocytes/immunology
Clone Cells
DNA Primers
Flow Cytometry
Humans
Immunophenotyping
Lyme Disease/*immunology
Lymphocyte Activation
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, gamma-delta/analysis/biosynthesis/*immunology
Synovial Fluid/*immunology
T-Lymphocyte Subsets/*immunology
Pubmed
Web of science
Open Access
Yes
Create date
24/01/2008 16:19
Last modification date
20/08/2019 15:00