Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis
Détails
Télécharger: BIB_4C55C8B1D132.P001.pdf (342.72 [Ko])
Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_4C55C8B1D132
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Apoptosis of Fashigh CD4+ synovial T cells by borrelia-reactive Fas-ligand(high) gamma delta T cells in Lyme arthritis
Périodique
Journal of Experimental Medicine
ISSN
0022-1007 (Print)
Statut éditorial
Publié
Date de publication
12/1996
Volume
184
Numéro
6
Pages
2109-17
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 1
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Dec 1
Résumé
The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore, synovial gamma delta T cell clones express elevated and sustained levels of the ligand for Fas (APO-1, CD95) compared to alpha beta T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes. The findings suggest that gamma delta T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process.
Mots-clé
*Antigens, CD95
*Apoptosis
Arthritis, Infectious/*immunology
Borrelia burgdorferi Group/*immunology
CD4-Positive T-Lymphocytes/*immunology/microbiology
CD8-Positive T-Lymphocytes/immunology
Clone Cells
DNA Primers
Flow Cytometry
Humans
Immunophenotyping
Lyme Disease/*immunology
Lymphocyte Activation
Polymerase Chain Reaction
Receptors, Antigen, T-Cell, gamma-delta/analysis/biosynthesis/*immunology
Synovial Fluid/*immunology
T-Lymphocyte Subsets/*immunology
Pubmed
Web of science
Open Access
Oui
Création de la notice
24/01/2008 16:19
Dernière modification de la notice
20/08/2019 15:00